abstract：BACKGROUND:We aimed to investigate the prevalence of undiagnosed abnormal glucose regulation (AGR, including diabetes and prediabetes) in patients undergoing coronary angiography (CAG) by using both glycated hemoglobin (HbA1c) and oral glucose tolerance test (OGTT) to screen, and to compare the performance of fasting p...

journal_title：Clinical chemistry and laboratory medicine

authors： Wang JS,Lee IT,Lee WJ,Lin SY,Fu CP,Lee WL,Liang KW,Sheu WH

更新日期：2015-08-01 00:00:00

abstract：:The recent revision of ISO15189 has further strengthened its position as the standard for accreditation for medical laboratories. Both for laboratories and their customers it is important that the scope of such accreditation is clear. Therefore the European co-operation for accreditation (EA) demands that the national...

journal_title：Clinical chemistry and laboratory medicine

authors： Thelen MH,Vanstapel FJ,Kroupis C,Vukasovic I,Boursier G,Barrett E,Bernabeu Andreu F,Brguljan PM,Brugnoni D,Lohmander M,Sprongl L,Vodnik T,Ghita I,Vaubourdolle M,Huisman W,Working Group Accreditation ISO\/CEN standards (WG-A

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:In large clinical trials, where RNA cannot be extracted immediately after sampling, preserving RNA in whole blood is a crucial initial step in obtaining robust qPCR data. The current golden standard for RNA preservation is costly and designed for time-consuming column-based RNA-extraction. We investigated th...

journal_title：Clinical chemistry and laboratory medicine

authors： Mærkedahl RB,Frøkiær H,Lauritzen L,Metzdorff SB

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:A large body of evidence suggests that not only cerebral but also systemic oxidative stress (OxS) might be involved in the pathogenesis of late onset Alzheimer's disease (LOAD) and vascular dementia (VAD), as well as of the prodromal phase of dementia, the so-called mild cognitive impairment (MCI). In the pr...

journal_title：Clinical chemistry and laboratory medicine

authors： Cervellati C,Romani A,Bergamini CM,Bosi C,Sanz JM,Passaro A,Zuliani G

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Biological variation (BV) data enable assessment of the significance of changes in serial measurements observed within a subject and are used to set analytical quality specifications. This data is available in a database held in Westgard website (http://www.westgard.com/biodatabase1.htm). Some limitations of...

journal_title：Clinical chemistry and laboratory medicine

authors： Carobene A

更新日期：2015-05-01 00:00:00

abstract：:The availability of so-called high-sensitivity troponin assays (hsTn) has scored a compelling goal for laboratory medicine, allowing the safe clinical application of international recommendations for the definition of acute myocardial infarction (AMI). However, the introduction of hsTn has not been welcomed by clinici...

journal_title：Clinical chemistry and laboratory medicine

authors： Ferraro S,Panteghini M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Reference laboratories providing reference services recognized by the Joint Committee for Traceability in Laboratory Medicine (JCTLM) must be accredited as calibration laboratories according to ISO 17025 and ISO 15195. These standards require laboratories to establish an uncertainty budget, in which the unce...

journal_title：Clinical chemistry and laboratory medicine

authors： Rami L,Canalias F

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The objective of this study was to examine the diagnostic accuracy of high-sensitivity cardiac troponin T (hs-cTnT) for acute myocardial infarction (AMI) in patients with renal insufficiency, since this population has a high incidence of non-AMI elevations of hs-cTnT. METHODS:In this prospective study, we e...

journal_title：Clinical chemistry and laboratory medicine

authors： Huang H,Zhu S,Wang W,Yi H,Du X,Nie X,He Y,Song H,Miao Q,Wang L,Li G

更新日期：2015-04-01 00:00:00

abstract：UNLABELLED:Background: Melanoma is the most aggressive skin cancer and, despite recent advances in therapy, about 20% of the patients die of their disease. Early relapse detection and monitoring of therapy response are crucial for efficient treatment of advanced melanoma. Thus, there is a need for blood-based biomarker...

journal_title：Clinical chemistry and laboratory medicine

authors： Kuhlmann JD,Wimberger P,Wilsch K,Fluck M,Suter L,Brunner G

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The timely detection of severe inflammatory conditions is of great importance for early therapy initiation and the patient's prognosis. The complex humoral and cellular processes involved in inflammation offer many opportunities for diagnostic testing, which are still unused in clinical practice. We investig...

journal_title：Clinical chemistry and laboratory medicine

authors： Hoffmann C,Hoffmann P,Zimmermann M

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Inflammation plays an imperative role in the etiology of cardiovascular diseases (CVD). The role of cytokines in the development and progression of idiopathic dilated cardiomyopathy (IDCM) is still uncertain. The current study was conducted to evaluate the association of tumor necrosis factor-α (TNF-α) -238G...

journal_title：Clinical chemistry and laboratory medicine

authors： Liaquat A,Shauket U,Ahmad W,Javed Q

更新日期：2015-02-01 00:00:00

abstract：:Laboratory and radiographic tests are often ordered unnecessarily. This excess testing has financial costs and is a burden on patients. We performed a systematic review to determine the effectiveness interventions to reduce test utilization by physicians. The MEDLINE and EMBASE databases were searched for the years 19...

journal_title：Clinical chemistry and laboratory medicine

authors： Kobewka DM,Ronksley PE,McKay JA,Forster AJ,van Walraven C

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:An effective quality control (QC) program requires the establishment of control limits within which the results of the QC sample is expected to fall. Traditionally, the mean plus/minus two standard deviations calculated for a set of QC sample results is used to establish control limits. Allowable total error...

journal_title：Clinical chemistry and laboratory medicine

authors： Dimech W,Vincini G,Karakaltsas M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Validation of blood collection tubes are important to determine the role of different collection tubes which influence the assurance of laboratory results. We compared two different tubes (Improvacuter™ and Becton Dickinson [BD] Vacutainer™) and investigated the effect of gel and storage time in comparison w...

journal_title：Clinical chemistry and laboratory medicine

authors： Zungun C,Yılmaz FM,Boru EG,Topcuoglu C

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Galectin-3 is an emerging biomarker of heart failure and of myocardial fibrosis risk. Monitoring of galectin-3 is essential during treatment with galectin-3 inhibitors. The aim of our study was to assess long-term biological variability in a specific group of unhealthy subjects. METHODS:The biological varia...

journal_title：Clinical chemistry and laboratory medicine

authors： Franeková J,Kubíček Z,Hošková L,Kotrbatá M,Sečník P,Kautzner J,Jabor A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Sickle cell disease is a major health burden in India. The aim of the study was to compare the diagnostic utility of two different approaches on automated high performance liquid chromatography (HPLC) for newborn screening for sickle cell disorders and other haemoglobinopathies in India. METHODS:Newborn bab...

journal_title：Clinical chemistry and laboratory medicine

authors： Upadhye DS,Jain DL,Trivedi YL,Nadkarni AH,Ghosh K,Colah RB

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:In chronic kidney diseases of various etiologies, the urinary excretion of uromodulin is usually decreased in parallel with the glomerular filtration rate. This study aimed to investigate whether serum uromodulin is associated with kidney function. METHODS:Within the framework of the Seniorlabor study, a su...

journal_title：Clinical chemistry and laboratory medicine

authors： Risch L,Lhotta K,Meier D,Medina-Escobar P,Nydegger UE,Risch M

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:International recommendations highlight the superior value of cardiac troponins (cTns) for early diagnosis of myocardial infarction along with analytical requirements of improved precision and detectability. In this multicenter study, we investigated the analytical performance of a new high sensitive cardiac...

journal_title：Clinical chemistry and laboratory medicine

authors： Krintus M,Kozinski M,Boudry P,Capell NE,Köller U,Lackner K,Lefèvre G,Lennartz L,Lotz J,Herranz AM,Nybo M,Plebani M,Sandberg MB,Schratzberger W,Shih J,Skadberg Ø,Chargui AT,Zaninotto M,Sypniewska G

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:With patients referred to emergency departments (EDs) for acute dyspnea, emergency physicians should consider all possible diagnoses and assess patients' risk stratification. Copeptin has been shown to have prognostic power for subsequent events, such as death and rehospitalization in patients admitted for d...

journal_title：Clinical chemistry and laboratory medicine

authors： Vetrone F,Santarelli S,Russo V,Lalle I,De Berardinis B,Magrini L,Di Stasio E,Salerno G,Cardelli P,Piccoli A,Codognotto M,Mion MM,Plebani M,Vettore G,Castello LM,Avanzi GC,Di Somma S

更新日期：2014-10-01 00:00:00

abstract：:Overcrowding of the emergency department (ED) is rapidly becoming a global challenge and a major source of concern for emergency physicians. The evaluation of cardiac biomarkers is critical for confirming diagnoses and expediting treatment decisions to reduce overcrowding, however, physicians currently face the dilemm...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Somma S,Zampini G,Vetrone F,Soto-Ruiz KM,Magrini L,Cardelli P,Ronco C,Maisel A,Peacock FW

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Thrombopoietin (TPO), a growth factor primarily involved in regulating thrombopoiesis, has been recently implicated in the pathogenesis of sepsis. TPO levels are, indeed, greatly increased in patients with sepsis compared to control subjects, and correlate with sepsis severity. The aim of this study was to e...

journal_title：Clinical chemistry and laboratory medicine

authors： Segre E,Pigozzi L,Lison D,Pivetta E,Bosco O,Vizio B,Suppo U,Turvani F,Morello F,Battista S,Moiraghi C,Montrucchio G,Lupia E

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:CD4+CD25+ forkhead box P3 (FOXP3)+ regulatory T cells (Tregs) accumulate in malignant tumors and negatively regulate antitumor immunity. However, the clinical significance of Tregs in HCC remains unclear. To determine the prognostic value of Tregs, we conducted a retrospective study on 264 patients with Barc...

journal_title：Clinical chemistry and laboratory medicine

authors： Li F,Guo Z,Lizée G,Yu H,Wang H,Si T

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The measurement of serum IgE aids in the diagnosis and management of atopic allergic disease and hyper-IgE immunodeficiency syndromes. The 2nd World Health Organization (WHO) International Reference Reagent (IRR) for serum IgE (75/502; 5000 IU/ampoule), is widely used to calibrate assays for serum IgE. Exhau...

journal_title：Clinical chemistry and laboratory medicine

authors： Thorpe SJ,Heath A,Fox B,Patel D,Egner W

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Lactase persistence is an inherited autosomal dominant trait that confers the ability to digest lactose after weaning. Lactose persistence is caused by single nucleotide variants in a regulatory element for the lactase gene (LCT). In Europeans, lactase persistence is associated with the nucleotide variant LC...

journal_title：Clinical chemistry and laboratory medicine

authors： Strand H,Sørensen LK,Ingebretsen OC

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Standardization of parathyroid hormone (PTH) assays is a major issue, especially in hemodialyzed (HD) patients. Two automated third generation PTH assays (Roche Elecsys and DiaSorin Liaison) are now available. These assays are specific for the (1-84) PTH and do not cross-react with the (7-84) fragment, contr...

journal_title：Clinical chemistry and laboratory medicine

authors： Cavalier E,Delanaye P,Lukas P,Carlisi A,Gadisseur R,Souberbielle JC

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer (CRC) screening. Availability of data on faecal haemoglobin concentrations (f-Hb) in three countries prompted an observational study on sex and age and the transferability of data across geography. METHODS:Single estimates of f-...

journal_title：Clinical chemistry and laboratory medicine

authors： Fraser CG,Rubeca T,Rapi S,Chen LS,Chen HH

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The increasing importance of anti-Müllerian hormone (AMH) for the assessment of ovarian reserve requires accurate AMH measurements. There have been conflicting results about the reliability of currently existing manual AMH assays. METHODS:Development of a high sensitive, fast and fully automated AMH assay o...

journal_title：Clinical chemistry and laboratory medicine

authors： Gassner D,Jung R

更新日期：2014-08-01 00:00:00

abstract：:Although the perioperative event rate has declined over the past 30 years, as a consequence of the developments in anesthesiology and surgical techniques, perioperative cardiovascular complications are still a significant clinical problem. At the end of the last century, a pooled analysis of several large studies foun...

journal_title：Clinical chemistry and laboratory medicine

authors： Clerico A,Emdin M,Passino C

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found to affect both atheroma and thrombosis. However, the association between PAI-1 levels and the incide...

journal_title：Clinical chemistry and laboratory medicine

authors： Nikolopoulos GK,Bagos PG,Tsangaris I,Tsiara CG,Kopterides P,Vaiopoulos A,Kapsimali V,Bonovas S,Tsantes AE

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The measurement of C-reactive protein (CRP) concentrations has been of interest as a classical marker of acute phase response; in addition, it has been of particular interest in cardiovascular risk stratification where high-sensitive measurements are necessary. Since CRP is able to bind phospholipids (mainly...

journal_title：Clinical chemistry and laboratory medicine

authors： Drieghe SA,Alsaadi H,Tugirimana PL,Delanghe JR

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The few available External Quality Assessment (EQA) programs on urinary sediment rarely include an evaluation of clinical cases. The present paper provides a descriptive analysis of clinical cases included in the Italian EQA program on urinary sediment. METHODS:Ten cases were presented over a 5-year period ...

journal_title：Clinical chemistry and laboratory medicine

authors： Fogazzi GB,Secchiero S,Garigali G,Plebani M

更新日期：2014-06-01 00:00:00

abstract：:The aim of this work was to assess the diagnostic value of anti-CCP-3 and anti-CCP-2 for the diagnosis of rheumatoid arthritis (RA) and determine whether anti-CCP-3 more accurately identifies patients with rheumatoid arthritis than anti-CCP-2. PubMed and CNKI databases were searched for studies published in English an...

journal_title：Clinical chemistry and laboratory medicine

authors： Zhang WC,Wu H,Chen WX

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The handling of cerebrospinal fluid (CSF) affects the biomarker quantification used to diagnose Alzheimer's disease (AD). Only specialized centers can test for AD markers. The precise timing and freezing is required to correctly measure these biomarkers. Therefore, the effects of CSF storage temperature and ...

journal_title：Clinical chemistry and laboratory medicine

authors： Klener J,Hofbauerová K,Bartoš A,Ríčný J,Rípová D,Kopecký V

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia (Hhcy) is considered an independent risk factor for vascular diseases and, more recently, for dementia. The methionine loading test (MLT) is useful for diagnosing additional subjects with moderate Hhcy. However, it is a complex and time-consuming procedure. A noninvasive test for the dia...

journal_title：Clinical chemistry and laboratory medicine

authors： Maldonado-Hernández J,Prina-Ojeda LV,Montalvo-Velarde I,Del Prado-Manríquez M,de Lourdes Barbosa-Cortés M,Repetto-Madrid M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Automated systems for antinuclear antibody analysis are being introduced. The aim was to evaluate whether automated quantitative reading of fluorescence intensity is clinically relevant and allows for value-added reporting of test results. METHODS:Consecutive samples (n=260) were used to correlate fluoresce...

journal_title：Clinical chemistry and laboratory medicine

authors： Schouwers S,Bonnet M,Verschueren P,Westhovens R,Blockmans D,Mariën G,Bossuyt X

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Highly-sensitive cardiac troponin (cTn) assays are being introduced into the market. In this study we argue that the classification of cTn assays into sensitive and highly-sensitive is flawed and recommend a more appropriate way to characterize analytical sensitivity of cTn assays. STUDY:The raw data of 225...

journal_title：Clinical chemistry and laboratory medicine

authors： Ungerer JP,Pretorius CJ

更新日期：2014-04-01 00:00:00

abstract：:Inflammatory bowel diseases (IBDs), which comprise the two major clinical subtypes, Crohn's disease and ulcerative colitis, incur high morbidity and potential mortality. The present study reviews data on the pathogenesis and diagnosis of IBDs. The pathogenesis depends on complex interactions between susceptibility gen...

journal_title：Clinical chemistry and laboratory medicine

authors： Basso D,Zambon CF,Plebani M

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Exosomes are cytoplasm containing vesicles released by many cells that can be found in several biological fluids including urine. Urinary exosomes are released from every segment of the nephron, are detectable in urine, constitutively contain RNA (small RNAs and mRNAs) and harbor unique subset of proteins, r...

journal_title：Clinical chemistry and laboratory medicine

authors： Channavajjhala SK,Rossato M,Morandini F,Castagna A,Pizzolo F,Bazzoni F,Olivieri O

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Over the last few decades, new synthetic insulin analogues have been developed. Their measurement is of prime importance in the investigation of hypoglycaemia, but their quantification is hampered by variable cross-reactivity with many insulin assays. For clinical analysis, it has now become essential to kno...

journal_title：Clinical chemistry and laboratory medicine

authors： Heurtault B,Reix N,Meyer N,Gasser F,Wendling MJ,Ratomponirina C,Jeandidier N,Sapin R,Agin A

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Prostate-specific antigen (PSA) is used as an outcome measure for relapsed disease in prostate cancer. Nonetheless, there are considerable concerns about its indiscriminate use as a surrogate endpoint for cell growth or survival. We hypothesized that treatment with a luteinizing hormone releasing hormone (LH...

journal_title：Clinical chemistry and laboratory medicine

authors： Wenisch JM,Mayr FB,Spiel AO,Radicioni M,Jilma B,Jilma-Stohlawetz P

更新日期：2014-03-01 00:00:00